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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:30778
Term: gallic acid
Definition: A trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5.
Chemical ID: MESH:D005707
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDGallic Acid results in decreased expression of VEGFA mRNAPMID:26530725
Vegfadecreases secretionISOVEGFA (Homo sapiens)6480464CTDGallic Acid results in decreased secretion of VEGFA proteinPMID:26530725
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDAKT1 protein inhibits the reaction [Gallic Acid results in decreased expression of VEGFA mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; HIF1A protein inhibits the reaction [Gallic Acid results in decreased expression of VEGFA mRNA]PMID:21420233 PMID:26530725
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