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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731644 Species: Homo sapiens RGD Object: Gene Symbol: RPS6KB1 Name: ribosomal protein S6 kinase, 70kDa, polypeptide 1

Acc ID: CHEBI:30621 Term: diarsenic trioxide Definition: An arsenic oxide that has formula As4O6. CasRN: 1327-53-3 Chemical ID: MESH:C006632

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	EXP		6480464	CTD	arsenic trioxide results in decreased activity of RPS6KB1 protein	PMID:14633726
decreases expression	EXP		6480464	CTD	arsenic trioxide results in decreased expression of RPS6KB1 protein modified form	PMID:20574048
increases phosphorylation	EXP		6480464	CTD	arsenic trioxide results in increased phosphorylation of RPS6KB1 protein	PMID:18048359
decreases phosphorylation	EXP		6480464	CTD	arsenic trioxide results in decreased phosphorylation of RPS6KB1 protein	PMID:21594580
multiple interactions	EXP		6480464	CTD	arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6KB1 protein]	PMID:21889928