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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708572
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arl6ip5
Name: ADP-ribosylation factor like GTPase 6 interacting protein 5
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arl6ip5increases expressionISOARL6IP5 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of ARL6IP5 proteinPMID:16430862
Arl6ip5increases response to substanceISOARL6IP5 (Homo sapiens)6480464CTDARL6IP5 protein results in increased susceptibility to Arsenic TrioxidePMID:18387645
Arl6ip5multiple interactionsISOARL6IP5 (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased abundance of Hydrogen Peroxide] which results in increased expression of ARL6IP5 protein; [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of ARL6IP5 mRNA; ARL6IP5 protein promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; ARL6IP5 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ARL6IP5 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [[Arsenic Trioxide results in increased abundance of Hydrogen Peroxide] which results in increased expression of ARL6IP5 protein]PMID:16468075 PMID:18387645
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