GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Arl6ip5 | increases expression | ISO | ARL6IP5 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of ARL6IP5 protein | PMID:16430862 | Arl6ip5 | increases response to substance | ISO | ARL6IP5 (Homo sapiens) | 6480464 | CTD | ARL6IP5 protein results in increased susceptibility to Arsenic Trioxide | PMID:18387645 | Arl6ip5 | multiple interactions | ISO | ARL6IP5 (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide results in increased abundance of Hydrogen Peroxide] which results in increased expression of ARL6IP5 protein; [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of ARL6IP5 mRNA; ARL6IP5 protein promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; ARL6IP5 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ARL6IP5 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [[Arsenic Trioxide results in increased abundance of Hydrogen Peroxide] which results in increased expression of ARL6IP5 protein] | PMID:16468075 PMID:18387645 | |
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