GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | JAK1 | decreases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased expression of JAK1 mRNA | PMID:33634982 | JAK1 | increases phosphorylation | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of JAK1 protein | PMID:19951532 | JAK1 | multiple interactions | EXP | | 6480464 | CTD | Arsenic Trioxide inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Arsenic Trioxide results in decreased expression of and results in decreased phosphorylation of JAK1 protein; JAK1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of NFKB1 protein]; JAK1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of RELA protein] | PMID:12492118 PMID:33634982 | |
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