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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd86
Name: CD86 molecule
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd86decreases expressionISOCD86 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of CD86 mRNAPMID:15761015
Cd86increases expressionISOCD86 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CD86 mRNAPMID:20458559
Cd86multiple interactionsISOCD86 (Homo sapiens)6480464CTD[CpG ODN 2216 co-treated with Arsenic Trioxide] results in decreased expression of CD86 protein; Arsenic Trioxide inhibits the reaction [CpG ODN 2216 results in increased expression of CD86 protein]PMID:32642412
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