• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619791 Species: Rattus norvegicus RGD Object: Gene Symbol: Bub1b Name: BUB1 mitotic checkpoint serine/threonine kinase B

Acc ID: CHEBI:30621 Term: diarsenic trioxide Definition: An arsenic oxide that has formula As4O6. CasRN: 1327-53-3 Chemical ID: MESH:C006632

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1316316	6480464	CTD	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin promotes the reaction [arsenic trioxide results in increased phosphorylation of BUB1B protein] KNK 437 promotes the reaction [arsenic trioxide results in increased phosphorylation of BUB1B protein]	PMID:19371599
increases phosphorylation	ISO	RGD:1316316	6480464	CTD	arsenic trioxide results in increased phosphorylation of BUB1B protein	PMID:19371599
multiple interactions	ISO	RGD:1316316	6480464	CTD	[arsenic trioxide co-treated with Paclitaxel] results in increased expression of BUB1B protein modified form [arsenic trioxide co-treated with Paclitaxel] promotes the reaction [BUB1B protein binds to CDC20 protein]	PMID:19781537