GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rara | decreases expression | ISO | RARA (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of RARA mRNA mutant form; Arsenic Trioxide results in decreased expression of RARA protein; Arsenic Trioxide results in decreased expression of RARA protein mutant form | PMID:23469683 PMID:27189198 PMID:27770503 | Rara | decreases response to substance | ISO | RARA (Homo sapiens) | 6480464 | CTD | RARA gene mutant form results in decreased susceptibility to Arsenic Trioxide | PMID:26728337 | Rara | increases degradation | ISO | RARA (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased degradation of RARA protein; Arsenic Trioxide results in increased degradation of RARA protein mutant form | PMID:15748426 PMID:16891316 PMID:17018029 PMID:17217047 PMID:9834237 | Rara | multiple interactions | ISO | Rara (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased degradation of and results in decreased expression of RARA protein | PMID:15688020 | Rara | multiple interactions | ISO | RARA (Homo sapiens) | 6480464 | CTD | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Arsenic Trioxide results in increased degradation of RARA protein]; [Tretinoin co-treated with Arsenic Trioxide] results in decreased expression of RARA mRNA alternative form; [Vorinostat co-treated with Arsenic Trioxide] results in decreased expression of RARA protein mutant form; Arsenic Trioxide promotes the reaction [puerarin results in decreased expression of RARA mRNA alternative form]; Arsenic Trioxide promotes the reaction [tetraarsenic tetrasulfide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]; Arsenic Trioxide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]; cobaltous chloride promotes the reaction [Arsenic Trioxide results in increased degradation of RARA protein mutant form]; RARA gene mutant form inhibits the reaction [Tretinoin inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]]; RARA gene mutant form inhibits the reaction [Tretinoin promotes the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; tetraarsenic tetrasulfide promotes the reaction [Arsenic Trioxide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]] | PMID:16330433 PMID:17018029 PMID:19225113 PMID:20416161 PMID:25003661 PMID:26110921 PMID:27189198 | | ||||||||||||||||||||||
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