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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1increases cleavageEXP 6480464CTDArsenic Trioxide results in increased cleavage of CASP1 proteinPMID:30660605
Casp1multiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein; Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; Taurine inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]PMID:30660605
Casp1decreases expressionISOCasp1 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of CASP1 mRNAPMID:15073043
Casp1increases activityISOCasp1 (Mus musculus)6480464CTDArsenic Trioxide results in increased activity of CASP1 proteinPMID:9734658
Casp1increases activityISOCASP1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased activity of CASP1 proteinPMID:9734658 PMID:9801394
Casp1increases expressionISOCasp1 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of CASP1 protein; Arsenic Trioxide results in increased expression of CASP1 protein modified formPMID:35226250
Casp1increases expressionISOCASP1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CASP1 mRNA; Arsenic Trioxide results in increased expression of CASP1 protein modified formPMID:24345465 PMID:35226250
Casp1multiple interactionsISOCasp1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Arsenic Trioxide inhibits the reaction [anthrax toxin results in increased cleavage of CASP1 protein]]; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; Arsenic Trioxide inhibits the reaction [anthrax toxin results in increased cleavage of CASP1 protein]; Arsenic Trioxide inhibits the reaction [Nigericin results in increased cleavage of CASP1 protein]; Arsenic Trioxide results in increased activity of and results in increased cleavage of CASP1 protein; Taurine inhibits the reaction [Arsenic Trioxide results in increased activity of and results in increased cleavage of CASP1 protein]PMID:23430110 PMID:24337744 PMID:30237538
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of CASP1 mRNA; AS3MT mRNA promotes the reaction [Arsenic Trioxide results in increased expression of CASP1 protein modified form]; CA 074 methyl ester inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; IGF2BP2 protein promotes the reaction [Arsenic Trioxide results in increased expression of CASP1 protein modified form]; METTL14 protein promotes the reaction [Arsenic Trioxide results in increased expression of CASP1 protein modified form]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; Taurine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]PMID:24345465 PMID:30237538 PMID:35226250
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