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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309799
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac1
Name: histone deacetylase 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac1multiple interactionsISOHDAC1 (Homo sapiens)6480464CTD[[Arsenic Trioxide results in increased phosphorylation of JUN protein] which binds to HDAC1 protein] which binds to CDKN1A promoter; [Arsenic Trioxide results in increased phosphorylation of JUN protein] which binds to HDAC1 protein; [Valproic Acid co-treated with Arsenic Trioxide] results in decreased expression of HDAC1 mRNA; Arsenic Trioxide promotes the reaction [[TGIF1 protein co-treated with HDAC1 protein] binds to CDKN1A promoter]; Arsenic Trioxide promotes the reaction [[TGIF1 protein co-treated with HDAC1 protein] results in decreased expression of CDKN1A mRNA]PMID:18210215 PMID:20074581 PMID:25815518
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