GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Map2k4 | increases response to substance | ISO | MAP2K4 (Homo sapiens) | 6480464 | CTD | MAP2K4 protein results in increased susceptibility to Arsenic Trioxide; MAP2K4 results in increased susceptibility to Arsenic Trioxide | PMID:14701702 PMID:18633430 | Map2k4 | increases response to substance | ISO | Map2k4 (Mus musculus) | 6480464 | CTD | MAP2K4 protein results in increased susceptibility to Arsenic Trioxide | PMID:16184197 | Map2k4 | multiple interactions | ISO | MAP2K4 (Homo sapiens) | 6480464 | CTD | MAP2K4 gene mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein]; MAP2K4 protein promotes the reaction [Arsenic Trioxide results in increased expression of HSPA6 mRNA]; MAP2K4 protein promotes the reaction [Arsenic Trioxide results in increased expression of HSPA6 protein]; MAP2K4 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of HSF1 protein] | PMID:14701702 PMID:15978632 | | ||||||||||||||||||||||
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