GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egfr | decreases expression | ISO | EGFR (Homo sapiens) | 6480464 | CTD | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EGFR mRNA | PMID:19150397 | Egfr | multiple interactions | ISO | Egfr (Mus musculus) | 6480464 | CTD | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide inhibits the reaction [EGF protein binds to EGFR protein] | PMID:6309801 | Egfr | multiple interactions | ISO | EGFR (Homo sapiens) | 6480464 | CTD | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of and results in increased activity of EGFR protein; EGFR mutant form inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; EGFR mutant form inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; EGFR mutant form inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MUC1 mutant form inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of and results in increased activity of EGFR protein] | PMID:22457794 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |