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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307040
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k4
Name: mitogen activated protein kinase kinase 4
Acc ID: CHEBI:30614
Term: benzo[a]pyrene diol epoxide I
Definition: An epoxide that has formula C20H14O3.
Chemical ID: MESH:D015123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k4decreases expressionISOMAP2K4 (Homo sapiens)6480464CTD7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAP2K4 mRNAPMID:19150397
Map2k4increases expressionISOMAP2K4 (Homo sapiens)6480464CTD7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MAP2K4 mRNAPMID:26238291
Map2k4increases phosphorylationISOMap2k4 (Mus musculus)6480464CTD7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of MAP2K4 proteinPMID:21501596
Map2k4multiple interactionsISOMap2k4 (Mus musculus)6480464CTDAG 1879 inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of MAP2K4 protein]; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of MAP2K4 protein]PMID:21501596
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