GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp1 | increases expression | EXP | | 6480464 | CTD | Silicon Dioxide results in increased expression of CASP1 mRNA | PMID:21602193 | Casp1 | affects expression | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | Silicon Dioxide analog affects the expression of CASP1 mRNA | PMID:25895662 | Casp1 | affects localization | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | Silicon Dioxide affects the localization of CASP1 protein | PMID:34766707 | Casp1 | increases activity | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | Silicon Dioxide results in increased activity of CASP1 protein | PMID:25351596 | Casp1 | increases cleavage | ISO | Casp1 (Mus musculus) | 6480464 | CTD | Silicon Dioxide results in increased cleavage of CASP1 protein | PMID:18403674 | Casp1 | increases expression | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | Silicon Dioxide results in increased expression of CASP1 mRNA; Silicon Dioxide results in increased expression of CASP1 protein | PMID:25351596 PMID:33012733 PMID:34766707 PMID:34969174 | Casp1 | multiple interactions | ISO | Casp1 (Mus musculus) | 6480464 | CTD | [Lipopolysaccharides co-treated with Silicon Dioxide] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of CASP1 protein; CA 074 methyl ester inhibits the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased activity of CASP1 protein]; CASP1 protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]; CASP1 protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA]]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of STAT2 mRNA]]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Silicon Dioxide results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [Silicon Dioxide results in increased cleavage of CASP1 protein]; Silicon Dioxide analog inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]; Silicon Dioxide analog inhibits the reaction [Uric Acid results in increased cleavage of CASP1 protein] | PMID:18403674 PMID:18604214 PMID:22273745 | Casp1 | multiple interactions | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | [Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of CASP1 protein; CASP1 protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of and results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Silicon Dioxide results in increased expression of CASP1 protein]; SCGB1A1 protein inhibits the reaction [Silicon Dioxide results in increased expression of CASP1 protein] | PMID:18604214 PMID:33012733 PMID:34969174 | | ||||||||||||||||||||||
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