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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:30537
Term: triphenylstannane
Definition: An organotin compound that has formula C18H16Sn.
Chemical ID: MESH:C030665
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionEXP 6480464CTDtriphenyltin results in decreased expression of PPARG mRNAPMID:32504733
Ppargaffects bindingISOPPARG (Homo sapiens)6480464CTDtriphenyltin binds to PPARG proteinPMID:25314719 PMID:27725436
Ppargincreases activityISOPparg (Mus musculus)6480464CTDtriphenyltin results in increased activity of PPARG proteinPMID:25777084
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDtriphenyltin binds to and results in increased activity of PPARG proteinPMID:24786373
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