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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806 Species: Rattus norvegicus RGD Object: Gene Symbol: Hmox1 Name: heme oxygenase (decycling) 1

Acc ID: CHEBI:30185 Term: zinc(0) Definition: An elemental zinc that has formula Zn. CasRN: 7440-66-6 Chemical ID: MESH:D015032

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:730901	6480464	CTD	Zinc promotes the reaction [HSF1 protein binds to HMOX1 promoter]	PMID:17244614
increases expression	ISO	RGD:730901	6480464	CTD	Zinc results in increased expression of HMOX1 mRNA	PMID:17244614 PMID:16870260
increases expression	EXP		6480464	CTD	Zinc results in increased expression of HMOX1 mRNA	PMID:17074742
increases expression	ISO	RGD:730901	6480464	CTD	Zinc results in increased expression of HMOX1 mRNA	PMID:16870260 PMID:17244614
multiple interactions	ISO	RGD:730901	6480464	CTD	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA] Acetylcysteine inhibits the reaction [Zinc results in increased expression of HMOX1 protein] Deferoxamine inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA] Acetylcysteine inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA] Deferoxamine inhibits the reaction [Zinc results in increased expression of HMOX1 protein]	PMID:22564156
increases expression	ISO	RGD:730901	6480464	CTD	Zinc results in increased expression of HMOX1 mRNA	PMID:22564156 PMID:17244614 PMID:16870260
increases expression	ISO	RGD:730901	6480464	CTD	Zinc results in increased expression of HMOX1 protein	PMID:22564156
increases expression	ISO	RGD:730901	6480464	CTD	Zinc results in increased expression of HMOX1 mRNA	PMID:22564156 PMID:16870260 PMID:17244614
increases expression	ISO	RGD:730901	6480464	CTD	Zinc results in increased expression of HMOX1 mRNA	PMID:16870260 PMID:17244614 PMID:22564156
multiple interactions	ISO	RGD:730901	6480464	CTD	[PCI 5002 co-treated with Zinc] results in increased expression of HMOX1 mRNA	PMID:18593933