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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9affects expressionISOMmp9 (Mus musculus)6480464CTDarsenite affects the expression of MMP9 mRNAPMID:15738583
Mmp9decreases expressionISOMmp9 (Mus musculus)6480464CTDarsenite results in decreased expression of MMP9 mRNAPMID:18929588
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDarsenite results in increased expression of MMP9 mRNA; arsenite results in increased expression of MMP9 proteinPMID:12488483 PMID:31646340
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDarsenite results in increased expression of MMP9 mRNAPMID:18296743
Mmp9increases methylationISOMMP9 (Homo sapiens)6480464CTDarsenite results in increased methylation of MMP9 promoterPMID:23974009
Mmp9increases secretionISOMMP9 (Homo sapiens)6480464CTDarsenite results in increased secretion of MMP9 proteinPMID:22011395
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDDietary Fats promotes the reaction [arsenite results in increased expression of MMP9 mRNA]; TRP53 protein affects the reaction [arsenite results in decreased expression of MMP9 mRNA]PMID:18296743 PMID:18929588
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