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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chukdecreases expressionISOCHUK (Homo sapiens)6480464CTDarsenite results in decreased expression of CHUK mRNA; arsenite results in decreased expression of CHUK proteinPMID:30177839
Chukdecreases expressionISOChuk (Mus musculus)6480464CTDarsenite results in decreased expression of CHUK mRNAPMID:33053406
Chukmultiple interactionsISOCHUK (Homo sapiens)6480464CTDarsenite inhibits the reaction [MAP3K14 protein results in increased activity of CHUK protein]; arsenite promotes the reaction [CHUK protein binds to EP300 protein modified form binds to CREBBP protein modified form]; arsenite promotes the reaction [EP300 protein binds to CHUK protein]; arsenite results in increased phosphorylation of and results in increased degradation of CHUK protein; CHUK protein affects the reaction [arsenite promotes the reaction [TP53 protein binds to EP300 protein binds to CREBBP protein]]; CHUK protein affects the reaction [arsenite promotes the reaction [TP53 protein binds to EP300 protein modified form binds to CREBBP protein modified form]]; CHUK protein promotes the reaction [arsenite results in increased acetylation of CREBBP protein]; CHUK protein promotes the reaction [arsenite results in increased acetylation of EP300 protein]; CHUK protein promotes the reaction [arsenite results in increased acetylation of TP53 protein]; CREBBP protein affects the reaction [arsenite results in increased phosphorylation of and results in increased degradation of CHUK protein]; EP300 protein affects the reaction [arsenite results in increased phosphorylation of and results in increased degradation of CHUK protein]PMID:10967126 PMID:33097607
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