GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Chuk | decreases expression | ISO | CHUK (Homo sapiens) | 6480464 | CTD | arsenite results in decreased expression of CHUK mRNA; arsenite results in decreased expression of CHUK protein | PMID:30177839 | Chuk | decreases expression | ISO | Chuk (Mus musculus) | 6480464 | CTD | arsenite results in decreased expression of CHUK mRNA | PMID:33053406 | Chuk | multiple interactions | ISO | CHUK (Homo sapiens) | 6480464 | CTD | arsenite inhibits the reaction [MAP3K14 protein results in increased activity of CHUK protein]; arsenite promotes the reaction [CHUK protein binds to EP300 protein modified form binds to CREBBP protein modified form]; arsenite promotes the reaction [EP300 protein binds to CHUK protein]; arsenite results in increased phosphorylation of and results in increased degradation of CHUK protein; CHUK protein affects the reaction [arsenite promotes the reaction [TP53 protein binds to EP300 protein binds to CREBBP protein]]; CHUK protein affects the reaction [arsenite promotes the reaction [TP53 protein binds to EP300 protein modified form binds to CREBBP protein modified form]]; CHUK protein promotes the reaction [arsenite results in increased acetylation of CREBBP protein]; CHUK protein promotes the reaction [arsenite results in increased acetylation of EP300 protein]; CHUK protein promotes the reaction [arsenite results in increased acetylation of TP53 protein]; CREBBP protein affects the reaction [arsenite results in increased phosphorylation of and results in increased degradation of CHUK protein]; EP300 protein affects the reaction [arsenite results in increased phosphorylation of and results in increased degradation of CHUK protein] | PMID:10967126 PMID:33097607 | |
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