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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733702
Species: Homo sapiens
RGD Object: Gene
Symbol: CACNA1E
Name: calcium voltage-gated channel subunit alpha1 E
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CACNA1Eaffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of CACNA1E exon; Benzo(a)pyrene affects the methylation of CACNA1E promoterPMID:27901495
CACNA1Eincreases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of CACNA1E 5' UTRPMID:27901495
CACNA1Eincreases mutagenesisEXP 6480464CTDBenzo(a)pyrene results in increased mutagenesis of CACNA1E genePMID:25435355
CACNA1Eaffects methylationISOCacna1e (Mus musculus)6480464CTDBenzo(a)pyrene affects the methylation of CACNA1E intronPMID:27901495
CACNA1Edecreases methylationISOCacna1e (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of CACNA1E 3' UTR; Benzo(a)pyrene results in decreased methylation of CACNA1E exonPMID:27901495
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