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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70822 Species: Homo sapiens RGD Object: Gene Symbol: FGF2 Name: fibroblast growth factor 2 (basic)

Acc ID: CHEBI:29865 Term: benzo[a]pyrene Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. CasRN: 50-32-8 Chemical ID: MESH:D001564

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]] Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased expression of ITGAV protein] alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased expression of [ITGAV protein binds to ITGB3 protein]] Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased expression of ITGB3 protein]	PMID:20876236
decreases response to substance	EXP		6480464	CTD	Benzo(a)pyrene results in decreased susceptibility to FGF2 protein	PMID:20876236
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of FGF2 mRNA	PMID:19181443