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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68997 Species: Homo sapiens RGD Object: Gene Symbol: IGF1R Name: insulin-like growth factor 1 receptor

Acc ID: CHEBI:29865 Term: benzo[a]pyrene Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. CasRN: 50-32-8 Chemical ID: MESH:D001564

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:10766	6480464	CTD	Benzo(a)pyrene results in decreased expression of IGF1R mRNA	PMID:21803694
decreases expression	EXP		6480464	CTD	Benzo(a)pyrene results in decreased expression of IGF1R mRNA	PMID:20106945
decreases expression	EXP		6480464	CTD	Benzo(a)pyrene results in decreased expression of IGF1R mRNA	PMID:20106945 PMID:22316170
decreases expression	EXP		6480464	CTD	Benzo(a)pyrene results in decreased expression of IGF1R mRNA	PMID:20106945 PMID:21632981 PMID:22316170
increases phosphorylation	EXP		6480464	CTD	Benzo(a)pyrene results in increased phosphorylation of IGF1R protein	PMID:9683191
multiple interactions	ISO	RGD:10766	6480464	CTD	AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of IGF1R mRNA]	PMID:15034205
decreases expression	ISO	RGD:10766	6480464	CTD	Benzo(a)pyrene results in decreased expression of IGF1R mRNA	PMID:15034205 PMID:21803694