GENE - CHEMICAL INTERACTIONS REPORT
RGD ID:
68469
Species:
Mus musculus
RGD Object:
Gene
Symbol:
Por
Name:
P450 (cytochrome) oxidoreductase
Acc ID:
CHEBI:29865
Term:
benzo[a]pyrene
Definition:
An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
CasRN:
50-32-8
Chemical ID:
MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
decreases expression ISO RGD:68468 6480464 CTD Benzo(a)pyrene results in decreased expression of POR mRNA PMID:20106945 multiple interactions EXP 6480464 CTD POR protein affects the reaction [Benzo(a)pyrene results in increased activity of and results in increased expression of NQO1 protein] PMID:21362632 increases expression EXP 6480464 CTD Benzo(a)pyrene results in increased expression of POR mRNA PMID:19770486 increases expression EXP 6480464 CTD Benzo(a)pyrene results in increased expression of POR protein PMID:19449198 multiple interactions EXP 6480464 CTD Capsaicin inhibits the reaction [Benzo(a)pyrene results in increased expression of POR protein] PMID:19449198 increases response to substance EXP 6480464 CTD POR protein results in increased susceptibility to Benzo(a)pyrene PMID:21376747 multiple interactions EXP 6480464 CTD POR protein affects the reaction [Benzo(a)pyrene affects the expression of SP1 protein] PMID:21987461 increases metabolic processing EXP 6480464 CTD POR protein results in increased metabolism of Benzo(a)pyrene PMID:21987461 multiple interactions EXP 6480464 CTD POR protein affects the reaction [Benzo(a)pyrene results in increased expression of EPHX1 protein] PMID:22759596 
