GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hsp90aa1 | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA | PMID:26466350 | Hsp90aa1 | multiple interactions | EXP | | 6480464 | CTD | Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA] | PMID:26466350 | Hsp90aa1 | decreases expression | ISO | Hsp90aa1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of HSP90AA1 mRNA | PMID:15034205 | Hsp90aa1 | decreases methylation | ISO | HSP90AA1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of HSP90AA1 promoter | PMID:27901495 | Hsp90aa1 | increases expression | ISO | HSP90AA1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA; Benzo(a)pyrene results in increased expression of HSP90AA1 protein | PMID:18061397 PMID:32234424 PMID:35487446 PMID:37390851 | Hsp90aa1 | increases expression | ISO | Hsp90aa1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA | PMID:19770486 PMID:21569818 PMID:37390851 | Hsp90aa1 | increases response to substance | ISO | HSP90AA1 (Homo sapiens) | 6480464 | CTD | HSP90AA1 protein results in increased susceptibility to Benzo(a)pyrene | PMID:35487446 | Hsp90aa1 | multiple interactions | ISO | HSP90AA1 (Homo sapiens) | 6480464 | CTD | 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA]; 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Benzo(a)pyrene results in increased expression of HSP90AA1 protein]; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of HSP90AA1 mRNA; HSP90AA1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of HSPA8 protein]; HSP90AA1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of LAMP2 mRNA]; HSP90AA1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of LAMP2 protein] | PMID:17690111 PMID:35487446 | Hsp90aa1 | multiple interactions | ISO | Hsp90aa1 (Mus musculus) | 6480464 | CTD | AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of HSP90AA1 mRNA] | PMID:15034205 | |
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