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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621812
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl3decreases expressionISOCxcl3 (Mus musculus)6480464CTDBenzo(a)pyrene metabolite results in decreased expression of CXCL1 mRNA; Benzo(a)pyrene results in decreased expression of CXCL1 mRNAPMID:19770486 PMID:32553695
Cxcl3increases expressionISOCXCL1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CXCL1 mRNAPMID:20064835 PMID:28351761
Cxcl3increases expressionISOCxcl3 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CXCL1 mRNAPMID:22228805
Cxcl3multiple interactionsISOCxcl3 (Mus musculus)6480464CTDBenzo(a)pyrene inhibits the reaction [Dextran Sulfate results in increased expression of CXCL1 mRNA]PMID:34998820
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