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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621805
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd17b3affects expressionISOHSD17B3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of HSD17B3 mRNAPMID:20106945
Hsd17b3decreases expressionISOHSD17B3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of HSD17B3 mRNAPMID:32234424
Hsd17b3decreases methylationISOHSD17B3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of HSD17B3 promoterPMID:27901495
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