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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621114
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ttn
Name: titin
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ttnaffects methylationISOTTN (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of TTN promoterPMID:27901495
Ttndecreases expressionISOTTN (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of TTN mRNAPMID:32234424
Ttndecreases expressionISOTtn (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of TTN mRNAPMID:22228805
Ttnincreases expressionISOTtn (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of TTN mRNAPMID:22228805
Ttnincreases methylationISOTtn (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of TTN exon; Benzo(a)pyrene results in increased methylation of TTN intronPMID:27901495
Ttnincreases mutagenesisISOTTN (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of TTN genePMID:25435355
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