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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620964
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkd1
Name: protein kinase D1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkd1decreases expressionISOPRKD1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PRKD1 mRNAPMID:20106945 PMID:21632981
Prkd1decreases expressionISOPrkd1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of PRKD1 mRNAPMID:15894712
Prkd1increases expressionISOPrkd1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of PRKD1 mRNAPMID:22228805
Prkd1increases methylationISOPRKD1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PRKD1 exon; Benzo(a)pyrene results in increased methylation of PRKD1 promoterPMID:27901495
Prkd1multiple interactionsISOPrkd1 (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PRKD1 mRNAPMID:15894712
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