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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620331
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pafah1b1
Name: platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pafah1b1affects methylationISOPAFAH1B1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PAFAH1B1 intron; Benzo(a)pyrene affects the methylation of PAFAH1B1 promoterPMID:27901495 PMID:30157460
Pafah1b1decreases expressionISOPAFAH1B1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PAFAH1B1 mRNAPMID:20064835
Pafah1b1decreases expressionISOPafah1b1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of PAFAH1B1 mRNAPMID:15034205
Pafah1b1multiple interactionsISOPafah1b1 (Mus musculus)6480464CTDAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of PAFAH1B1 mRNA]; AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of PAFAH1B1 mRNA]PMID:15034205
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