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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61822
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnj10
Name: potassium inwardly-rectifying channel, subfamily J, member 10
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj10affects methylationISOKCNJ10 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of KCNJ10 5' UTRPMID:27901495
Kcnj10decreases expressionISOKCNJ10 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of KCNJ10 mRNAPMID:20106945 PMID:21632981 PMID:26238291
Kcnj10increases expressionISOKcnj10 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of KCNJ10 mRNAPMID:32417428
Kcnj10increases methylationISOKCNJ10 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of KCNJ10 3' UTRPMID:27901495
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