GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pgr | increases methylation | ISO | PGR (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of PGR exon; Benzo(a)pyrene results in increased methylation of PGR promoter | PMID:27901495 | Pgr | multiple interactions | ISO | PGR (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; Benzo(a)pyrene inhibits the reaction [Estradiol results in increased expression of PGR mRNA] | PMID:10822009 PMID:26022396 | |
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