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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3285
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdgfrb
Name: platelet derived growth factor receptor beta
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdgfrbaffects methylationISOPDGFRB (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PDGFRB intronPMID:30157460
Pdgfrbdecreases expressionISOPdgfrb (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of PDGFRB mRNAPMID:21569818
Pdgfrbdecreases expressionISOPDGFRB (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PDGFRB mRNAPMID:22316170 PMID:26238291
Pdgfrbdecreases methylationISOPDGFRB (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of PDGFRB promoterPMID:27901495
Pdgfrbincreases expressionISOPdgfrb (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of PDGFRB mRNAPMID:15034205 PMID:22228805
Pdgfrbincreases expressionISOPDGFRB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of PDGFRB mRNAPMID:32234424
Pdgfrbincreases methylationISOPDGFRB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PDGFRB 5' UTRPMID:27901495
Pdgfrbmultiple interactionsISOPdgfrb (Mus musculus)6480464CTDAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of PDGFRB mRNA]PMID:15034205
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