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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3227
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Odc1
Name: ornithine decarboxylase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Odc1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of ODC1 mRNAPMID:21839799
Odc1decreases expressionISOODC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ODC1 mRNAPMID:22316170
Odc1increases expressionISOOdc1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ODC1 mRNAPMID:19146932 PMID:19770486
Odc1increases expressionISOODC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ODC1 mRNAPMID:18061397
Odc1increases methylationISOODC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ODC1 promoterPMID:27901495
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