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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3227 Species: Rattus norvegicus RGD Object: Gene Symbol: Odc1 Name: ornithine decarboxylase 1

Acc ID: CHEBI:29865 Term: benzo[a]pyrene Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. CasRN: 50-32-8 Chemical ID: MESH:D001564

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1551973	6480464	CTD	Benzo(a)pyrene results in increased expression of ODC1 mRNA	PMID:19770486 PMID:19146932
increases expression	ISO	RGD:1551973	6480464	CTD	Benzo(a)pyrene results in increased expression of ODC1 mRNA	PMID:19146932
increases expression	ISO	RGD:731324	6480464	CTD	Benzo(a)pyrene results in increased expression of ODC1 mRNA	PMID:18061397
increases expression	ISO	RGD:1551973	6480464	CTD	Benzo(a)pyrene results in increased expression of ODC1 mRNA	PMID:19146932 PMID:19770486
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of ODC1 mRNA	PMID:21839799
decreases expression	ISO	RGD:731324	6480464	CTD	Benzo(a)pyrene results in decreased expression of ODC1 mRNA	PMID:22316170