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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2604
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgb
Name: fibrinogen beta chain
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgbdecreases expressionISOFGB (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of FGB mRNAPMID:22178795 PMID:26238291 PMID:32234424
Fgbdecreases expressionISOFgb (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of FGB mRNAPMID:19770486 PMID:21715664
Fgbincreases expressionISOFGB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of FGB mRNAPMID:22316170
Fgbincreases methylationISOFGB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of FGB exonPMID:27901495
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