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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfraffects methylationISOEGFR (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of EGFR promoterPMID:27901495
Egfrdecreases expressionISOEgfr (Mus musculus)6480464CTDBenzo(a)pyrene metabolite results in decreased expression of EGFR mRNA; Benzo(a)pyrene results in decreased expression of EGFR mRNAPMID:19770486 PMID:21803694 PMID:32553695
Egfrdecreases methylationISOEgfr (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of EGFR 3' UTR; Benzo(a)pyrene results in decreased methylation of EGFR exonPMID:27901495
Egfrincreases expressionISOEGFR (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of EGFR mRNAPMID:19181443
Egfrincreases phosphorylationISOEGFR (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased phosphorylation of EGFR proteinPMID:19181443
Egfrincreases response to substanceISOEGFR (Homo sapiens)6480464CTDEGFR protein results in increased susceptibility to Benzo(a)pyrenePMID:8608954
Egfrmultiple interactionsISOEgfr (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene inhibits the reaction [EGF protein binds to EGFR protein]]; Benzo(a)pyrene inhibits the reaction [EGF protein binds to EGFR protein]PMID:6309801
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