GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egfr | affects methylation | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of EGFR promoter | PMID:27901495 | Egfr | decreases expression | ISO | Egfr (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene metabolite results in decreased expression of EGFR mRNA; Benzo(a)pyrene results in decreased expression of EGFR mRNA | PMID:19770486 PMID:21803694 PMID:32553695 | Egfr | decreases methylation | ISO | Egfr (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of EGFR 3' UTR; Benzo(a)pyrene results in decreased methylation of EGFR exon | PMID:27901495 | Egfr | increases expression | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of EGFR mRNA | PMID:19181443 | Egfr | increases phosphorylation | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased phosphorylation of EGFR protein | PMID:19181443 | Egfr | increases response to substance | ISO | EGFR (Homo sapiens) | 6480464 | CTD | EGFR protein results in increased susceptibility to Benzo(a)pyrene | PMID:8608954 | Egfr | multiple interactions | ISO | Egfr (Mus musculus) | 6480464 | CTD | AHR protein affects the reaction [Benzo(a)pyrene inhibits the reaction [EGF protein binds to EGFR protein]]; Benzo(a)pyrene inhibits the reaction [EGF protein binds to EGFR protein] | PMID:6309801 | |
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