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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Csf1r
Name: colony stimulating factor 1 receptor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Csf1rdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of CSF1R proteinPMID:21467743
Csf1raffects methylationISOCSF1R (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CSF1R 5' UTR; Benzo(a)pyrene affects the methylation of CSF1R intron; Benzo(a)pyrene affects the methylation of CSF1R promoterPMID:27901495 PMID:30157460
Csf1rdecreases expressionISOCsf1r (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CSF1R mRNAPMID:15034205
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