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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Brca1
Name: BRCA1, DNA repair associated
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brca1affects methylationISOBRCA1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of BRCA1 promoterPMID:27901495
Brca1affects response to substanceISOBrca1 (Mus musculus)6480464CTDBRCA1 protein affects the susceptibility to Benzo(a)pyrenePMID:21507987
Brca1affects response to substanceISOBRCA1 (Homo sapiens)6480464CTDBRCA1 protein affects the susceptibility to Benzo(a)pyrenePMID:21507987
Brca1decreases expressionISOBrca1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of BRCA1 mRNAPMID:17942131
Brca1decreases expressionISOBRCA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of BRCA1 mRNAPMID:11782367 PMID:18247414 PMID:20064835 PMID:22048643
Brca1increases expressionISOBrca1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of BRCA1 mRNAPMID:20713471
Brca1increases expressionISOBRCA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of BRCA1 mRNAPMID:28461126 PMID:32234424 PMID:32890658
Brca1multiple interactionsISOBRCA1 (Homo sapiens)6480464CTDARNT protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]; Benzo(a)pyrene inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]; Benzo(a)pyrene promotes the reaction [[BRCA1 protein binds to NFE2L2 promoter] which results in increased expression of NFE2L2 mRNA]; Benzo(a)pyrene promotes the reaction [[BRCA1 protein binds to UGT1A1 promoter] which results in increased expression of UGT1A1 mRNA]; Benzo(a)pyrene promotes the reaction [[BRCA1 protein binds to UGT1A9 promoter] which results in increased expression of UGT1A9 mRNA]; Benzo(a)pyrene promotes the reaction [BRCA1 protein binds to NFE2L2 promoter]; Benzo(a)pyrene promotes the reaction [BRCA1 protein binds to UGT1A1 promoter]; Benzo(a)pyrene promotes the reaction [BRCA1 protein binds to UGT1A9 promoter]; BRCA1 inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]; BRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to NFE2L2 promoter]]; BRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A1 promoter]]; BRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to UGT1A9 promoter]]; BRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; BRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 protein]; BRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A1 mRNA]; BRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A1 protein]; BRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 mRNA]; BRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of UGT1A9 protein]; NFE2L2 protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]; NFE2L2 protein inhibits the reaction [BRCA1 inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; TP53 protein promotes the reaction [Benzo(a)pyrene results in decreased expression of BRCA1 mRNA]; UGT1A1 protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]; UGT1A9 protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]PMID:11782367 PMID:16489025 PMID:21507987 PMID:22192953
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