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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2044
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adh1c
Name: alcohol dehydrogenase 1C (class I), gamma polypeptide
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adh1caffects methylationISOADH1C (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ADH1C promoterPMID:27901495
Adh1cdecreases expressionISOADH1C (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ADH1C mRNAPMID:32234424
Adh1cincreases expressionISOAdh1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ADH1 mRNAPMID:22228805
Adh1cincreases mutagenesisISOADH1C (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of ADH1C genePMID:25435355
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