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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2025
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta1
Name: actin, alpha 1, skeletal muscle
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta1affects expressionISOActa1 (Mus musculus)6480464CTDBenzo(a)pyrene affects the expression of ACTA1 mRNAPMID:20127859
Acta1affects methylationISOACTA1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ACTA1 5' UTRPMID:27901495
Acta1decreases expressionISOACTA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ACTA1 mRNAPMID:21632981 PMID:22316170
Acta1increases expressionISOACTA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ACTA1 mRNAPMID:26238291
Acta1increases methylationISOACTA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ACTA1 3' UTR; Benzo(a)pyrene results in increased methylation of ACTA1 promoterPMID:27901495
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