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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2013
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acadsb
Name: acyl-CoA dehydrogenase, short/branched chain
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acadsbdecreases expressionISOACADSB (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ACADSB mRNA; Benzo(a)pyrene results in decreased expression of ACADSB proteinPMID:32234424 PMID:33278487
Acadsbdecreases expressionISOAcadsb (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ACADSB mRNAPMID:19770486
Acadsbdecreases methylationISOACADSB (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of ACADSB 3' UTRPMID:27901495
Acadsbincreases expressionISOACADSB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ACADSB mRNAPMID:16545412
Acadsbincreases expressionISOAcadsb (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ACADSB mRNAPMID:15034205 PMID:22228805
Acadsbmultiple interactionsISOAcadsb (Mus musculus)6480464CTDAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ACADSB mRNA]; Benzo(a)pyrene promotes the reaction [AHR protein binds to ACADSB promoter]PMID:15034205 PMID:19654925
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