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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564397 Species: Rattus norvegicus RGD Object: Gene Symbol: Hs6st2 Name: heparan sulfate 6-O-sulfotransferase 2

Acc ID: CHEBI:29865 Term: benzo[a]pyrene Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. CasRN: 50-32-8 Chemical ID: MESH:D001564

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1557635	6480464	CTD	Benzo(a)pyrene results in decreased expression of HS6ST2 mRNA	PMID:15894712
multiple interactions	ISO	RGD:1557635	6480464	CTD	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of HS6ST2 mRNA	PMID:15894712
affects expression	ISO	RGD:1605906	6480464	CTD	Benzo(a)pyrene affects the expression of HS6ST2 mRNA	PMID:22316170
decreases expression	ISO	RGD:1557635	6480464	CTD	Benzo(a)pyrene results in decreased expression of HS6ST2 mRNA	PMID:15034205 PMID:15894712