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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359092
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt10
Name: keratin 10
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krt10increases methylationISOKRT10 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of KRT10 exonPMID:27901495
Krt10increases methylationISOKrt10 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of KRT10 exon; Benzo(a)pyrene results in increased methylation of KRT10 intronPMID:27901495
Krt10multiple interactionsISOKRT10 (Homo sapiens)6480464CTD[Soot co-treated with Benzo(a)pyrene] results in decreased expression of KRT10 protein modified formPMID:24464499
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