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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350169 Species: Homo sapiens RGD Object: Gene Symbol: SERTAD2 Name: SERTA domain containing 2

Acc ID: CHEBI:29865 Term: benzo[a]pyrene Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. CasRN: 50-32-8 Chemical ID: MESH:D001564

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1557431	6480464	CTD	Benzo(a)pyrene affects the reaction [AHR protein binds to SERTAD2 promoter]	PMID:19654925
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of SERTAD2 mRNA	PMID:20106945 PMID:20064835
multiple interactions	ISO	RGD:1557431	6480464	CTD	[Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of SERTAD2 mRNA	PMID:21715664
decreases expression	ISO	RGD:1557431	6480464	CTD	Benzo(a)pyrene results in decreased expression of SERTAD2 mRNA	PMID:20127859
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of SERTAD2 mRNA	PMID:20064835 PMID:20106945
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of SERTAD2 mRNA	PMID:21871943 PMID:20106945 PMID:20064835
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of SERTAD2 mRNA	PMID:20064835 PMID:20106945 PMID:21871943
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of SERTAD2 mRNA	PMID:20064835 PMID:20106945 PMID:21871943 PMID:22316170
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of SERTAD2 mRNA	PMID:20064835 PMID:20106945 PMID:21632981 PMID:21871943 PMID:22316170