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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346266 Species: Homo sapiens RGD Object: Gene Symbol: FAS Name: Fas (TNF receptor superfamily, member 6)

Acc ID: CHEBI:29865 Term: benzo[a]pyrene Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. CasRN: 50-32-8 Chemical ID: MESH:D001564

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Nitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of FAS protein]	PMID:16041517
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:20064835 PMID:20106945
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of FAS protein	PMID:16041517
multiple interactions	ISO	RGD:1552455	6480464	CTD	[Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of FAS mRNA	PMID:21715664
increases expression	ISO	RGD:1552455	6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:21715664
affects expression	EXP		6480464	CTD	Benzo(a)pyrene affects the expression of FAS mRNA	PMID:21873647
increases expression	ISO	RGD:1552455	6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:19770486 PMID:21715664
increases expression	ISO	RGD:1552455	6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:21715664 PMID:19770486
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:20064835 PMID:21871943 PMID:20106945
increases expression	ISO	RGD:1552455	6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:21715664 PMID:21569818 PMID:19770486
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:21871943 PMID:20106945 PMID:20064835
increases expression	ISO	RGD:1552455	6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:21715664 PMID:19770486 PMID:21569818
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:21871943 PMID:20064835 PMID:20106945
increases expression	ISO	RGD:1552455	6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:19770486 PMID:21715664 PMID:21569818
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:20064835 PMID:20106945 PMID:21871943 PMID:22316170
increases expression	ISO	RGD:1552455	6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:19770486 PMID:21569818 PMID:21715664 PMID:22228805
decreases expression	ISO	RGD:619831	6480464	CTD	Benzo(a)pyrene results in decreased expression of FAS protein	PMID:21467743
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:20064835 PMID:20106945 PMID:21632981 PMID:21871943 PMID:22316170
increases expression	EXP		6480464	CTD	Benzo(a)pyrene results in increased expression of FAS mRNA	PMID:20064835 PMID:20106945 PMID:21632981 PMID:21871943 PMID:22316170 PMID:22889811