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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309229
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agpat2
Name: 1-acylglycerol-3-phosphate O-acyltransferase 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agpat2affects methylationISOAGPAT2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of AGPAT2 intron; Benzo(a)pyrene affects the methylation of AGPAT2 promoterPMID:27901495 PMID:30157460
Agpat2decreases expressionISOAGPAT2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of AGPAT2 mRNAPMID:20106945 PMID:32234424
Agpat2decreases expressionISOAgpat2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of AGPAT2 mRNAPMID:19770486 PMID:21715664 PMID:22228805
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