GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mdm2 | decreases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of MDM2 protein | PMID:21467743 | Mdm2 | decreases expression | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of MDM2 mRNA | PMID:30562542 | Mdm2 | increases expression | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of MDM2 mRNA; Benzo(a)pyrene results in increased expression of MDM2 protein; Benzo(a)pyrene results in increased expression of MDM2 protein modified form | PMID:10837373 PMID:18418871 PMID:20106945 PMID:21632981 PMID:21871943 PMID:22044530 PMID:22316170 PMID:22889811 PMID:25690898 PMID:26238291 PMID:27694624 PMID:28461126 PMID:30562542 PMID:31555880 PMID:32234424 | Mdm2 | increases expression | ISO | Mdm2 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene metabolite results in increased expression of MDM2 mRNA; Benzo(a)pyrene results in increased expression of MDM2 mRNA | PMID:18656336 PMID:19146932 PMID:19770486 PMID:21569818 PMID:22228805 PMID:22610609 PMID:23735875 PMID:32553695 PMID:9006915 | Mdm2 | increases phosphorylation | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased phosphorylation of MDM2 protein | PMID:20840854 PMID:25744307 | Mdm2 | multiple interactions | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | 2,4,4'-trichlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]; 2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of MDM2 mRNA; Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]; Benzo(a)pyrene results in increased expression of and results in increased phosphorylation of MDM2 protein; Cadmium Chloride affects the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]; MAPK3 mutant form inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]; MDM2 mutant form promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; Simvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]]; TP53 affects the reaction [Benzo(a)pyrene results in increased expression of MDM2 mRNA]; U 0126 inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein] | PMID:10837373 PMID:15625077 PMID:17690111 PMID:18096571 PMID:20840854 PMID:25744307 | Mdm2 | multiple interactions | ISO | Mdm2 (Mus musculus) | 6480464 | CTD | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA | PMID:27858113 | | ||||||||||||||||||||||
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