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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10698
Species: Mus musculus
RGD Object: Gene
Symbol: Gstm2
Name: glutathione S-transferase, mu 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of GSTM2 mRNAPMID:20127859
Gstm2increases activityEXP 6480464CTDBenzo(a)pyrene results in increased activity of GSTM2 proteinPMID:30938511
Gstm2increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of GSTM2 mRNAPMID:27195522 PMID:32417428
Gstm2affects methylationISOGSTM2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of GSTM2 promoterPMID:27901495
Gstm2decreases expressionISOGstm2 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of GSTM2 mRNAPMID:21839799
Gstm2decreases expressionISOGSTM2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of GSTM2 mRNAPMID:32234424
Gstm2decreases response to substanceISOGSTM2 (Homo sapiens)6480464CTDGSTM2 protein results in decreased susceptibility to Benzo(a)pyrenePMID:19900515
Gstm2increases expressionISOGSTM2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of GSTM2 mRNAPMID:33411230
Gstm2increases methylationISOGSTM2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of GSTM2 5' UTR; Benzo(a)pyrene results in increased methylation of GSTM2 exonPMID:27901495
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