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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of VEGFA mRNA; sodium arsenite results in decreased expression of VEGFA proteinPMID:20598115 PMID:21964460 PMID:35314868
Vegfaincreases expressionEXP 6480464CTDsodium arsenite results in increased expression of VEGFA; sodium arsenite results in increased expression of VEGFA proteinPMID:21167264 PMID:26439596
Vegfamultiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of VEGFA protein; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of VEGFA]; Tretinoin inhibits the reaction [sodium arsenite results in decreased expression of VEGFA mRNA]; Tretinoin inhibits the reaction [sodium arsenite results in decreased expression of VEGFA protein]PMID:21964460 PMID:26439596 PMID:33904385
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of VEGFA mRNAPMID:22199297 PMID:22310326 PMID:34032870
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDsodium arsenite results in increased expression of VEGFA mRNA; sodium arsenite results in increased expression of VEGFA proteinPMID:11641398 PMID:12482858 PMID:12703962 PMID:12760830 PMID:15788408 PMID:19622383 PMID:20083128 PMID:20886546 PMID:21167264 PMID:22859221 PMID:23968725 PMID:24188932 PMID:24431212 PMID:26735578 PMID:30090327 PMID:32890875
Vegfaincreases expressionISOVegfa (Mus musculus)6480464CTDsodium arsenite results in increased expression of VEGFA mRNAPMID:12482858 PMID:16014739 PMID:36209798
Vegfaincreases secretionISOVEGFA (Homo sapiens)6480464CTDsodium arsenite results in increased secretion of VEGFA proteinPMID:12703962 PMID:19622383
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; [Ethanol co-treated with sodium arsenite] results in increased expression of VEGFA mRNA; [Oligodeoxyribonucleotides, Antisense results in decreased expression of EPAS1 protein] inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; [sodium arsenite co-treated with ATF4 protein] results in increased expression of VEGFA mRNA; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased secretion of VEGFA protein]; AKT activator SC79 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]]; ATF4 protein affects the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; bisindolylmaleimide I inhibits the reaction [[Ethanol co-treated with sodium arsenite] results in increased expression of VEGFA mRNA]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; Cycloheximide inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; Decitabine inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; Decitabine inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; ERBB2 protein affects the reaction [sodium arsenite results in increased expression of VEGFA protein]; Glutathione inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; Go 6976 inhibits the reaction [[Ethanol co-treated with sodium arsenite] results in increased expression of VEGFA mRNA]; HMOX1 protein affects the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; HMOX1 protein affects the reaction [sodium arsenite results in increased expression of VEGFA protein]; Lapatinib inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; MALAT1 mRNA promotes the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; PRKAA1 protein affects the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; PRKAA1 protein affects the reaction [sodium arsenite results in increased secretion of VEGFA protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; sodium arsenite promotes the reaction [ATF4 protein binds to VEGFA promoter]; U 0126 inhibits the reaction [ERBB2 protein affects the reaction [sodium arsenite results in increased expression of VEGFA protein]]; U 0126 inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; U 0126 inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]PMID:11641398 PMID:12482858 PMID:15788408 PMID:16678800 PMID:18182400 PMID:18210215 PMID:19622383 PMID:20083128 PMID:21167264 PMID:22859221 PMID:23968725 PMID:26735578 PMID:30090327 PMID:32890875
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of VEGFA mRNAPMID:34876320
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