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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityEXP 6480464CTDsodium arsenite results in increased activity of CASP9 proteinPMID:29278859 PMID:30408888
Casp9increases expressionEXP 6480464CTDsodium arsenite results in increased expression of CASP9 mRNA; sodium arsenite results in increased expression of CASP9 proteinPMID:20830294 PMID:23906897 PMID:24184500
Casp9multiple interactionsEXP 6480464CTD[Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in increased expression of CASP9 mRNA]]; [SERPINF1 protein co-treated with sodium arsenite] results in increased activity of CASP9 protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP9 protein; Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein]; Calcium affects the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; IL1RN protein inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]; lead acetate promotes the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate promotes the reaction [sodium arsenite results in increased expression of CASP9 mRNA]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite promotes the reaction [lead acetate results in increased expression of CASP9 mRNA]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]; sodium arsenite promotes the reaction [lead acetate results in increased expression of CASP9 mRNA]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP9 protein]; Taurine inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein]; Zinc affects the reaction [sodium arsenite results in increased expression of CASP9 mRNA]PMID:20830294 PMID:23906897 PMID:24184500 PMID:26396915 PMID:29278859 PMID:30408888 PMID:30835071
Casp9affects response to substanceISOCASP9 (Homo sapiens)6480464CTDCASP9 protein affects the susceptibility to sodium arsenitePMID:23219847
Casp9decreases expressionISOCASP9 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of CASP9 proteinPMID:26404762 PMID:29039521
Casp9increases activityISOCasp9 (Mus musculus)6480464CTDsodium arsenite results in increased activity of CASP9 proteinPMID:20006689
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDsodium arsenite results in increased activity of CASP9 proteinPMID:23681673
Casp9increases cleavageISOCasp9 (Mus musculus)6480464CTDsodium arsenite results in increased cleavage of CASP9 proteinPMID:29854073
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDsodium arsenite results in increased cleavage of CASP9 proteinPMID:24100277
Casp9increases expressionISOCasp9 (Mus musculus)6480464CTDsodium arsenite results in increased expression of CASP9 proteinPMID:29763682
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of CASP9 mRNA; sodium arsenite results in increased expression of CASP9 protein; sodium arsenite results in increased expression of CASP9 protein modified formPMID:30460075 PMID:35142421
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTD[GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein]; salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP9 protein]PMID:20006689 PMID:29763682 PMID:29854073
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein modified form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein]; [acetyl-leucyl-glutamyl-histidyl-aspartal results in decreased activity of CASP9 protein] which results in decreased susceptibility to sodium arsenite; [delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP9 protein; [sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP9 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP9 protein; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP9 protein]; ATF3 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP9 protein]; HTS 466284 inhibits the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; HTS 466284 inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein modified form]; HTS 466284 inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein]; sodium arsenite results in increased cleavage of and results in increased activity of CASP9 protein; tetramethylpyrazine inhibits the reaction [sodium arsenite results in decreased expression of CASP9 protein]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CASP9 protein modified form]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CASP9 protein]PMID:19082730 PMID:23219847 PMID:23681673 PMID:26404762 PMID:30125548 PMID:33921748 PMID:35142421
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