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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Faslgincreases expressionEXP 6480464CTDsodium arsenite results in increased expression of FASLG proteinPMID:20946910
Faslgmultiple interactionsEXP 6480464CTD[Atorvastatin co-treated with Acetylcysteine] inhibits the reaction [sodium arsenite results in increased expression of FASLG protein]PMID:20946910
Faslgaffects activityISOFASLG (Homo sapiens)6480464CTDsodium arsenite affects the activity of FASLG proteinPMID:18977016
Faslgmultiple interactionsISOFASLG (Homo sapiens)6480464CTD[sodium arsenite co-treated with FASLG protein] results in increased cleavage of CASP3 protein; [sodium arsenite co-treated with FASLG protein] results in increased cleavage of PARP1 protein; [sodium arsenite co-treated with N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide] results in increased localization of and results in increased stability of FASLG proteinPMID:16487513 PMID:18977016
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