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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3610
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rxraaffects methylationISORXRA (Homo sapiens)6480464CTDsodium arsenite affects the methylation of RXRA genePMID:28589171
Rxradecreases expressionISORxra (Mus musculus)6480464CTDsodium arsenite results in decreased expression of RXRA mRNAPMID:19822182 PMID:23221991
Rxradecreases expressionISORXRA (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of RXRA mRNA; sodium arsenite results in decreased expression of RXRA proteinPMID:15833926 PMID:30528433 PMID:32201329
Rxraincreases expressionISORXRA (Homo sapiens)6480464CTDsodium arsenite results in increased expression of RXRA mRNAPMID:19084030
Rxramultiple interactionsISORxra (Mus musculus)6480464CTDsodium arsenite inhibits the reaction [[alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA]PMID:22310326
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