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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of NOS3 mRNAPMID:25058445 PMID:37120063
Nos3increases expressionEXP 6480464CTDsodium arsenite results in increased expression of NOS3 proteinPMID:25218292
Nos3multiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NOS3 protein; Arsenic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NOS3 protein]; Atorvastatin inhibits the reaction [sodium arsenite results in decreased expression of and results in decreased phosphorylation of NOS3 protein]; Atorvastatin inhibits the reaction [sodium arsenite results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOS3 protein]; sodium arsenite results in decreased expression of and results in decreased phosphorylation of NOS3 proteinPMID:25058445 PMID:25218292 PMID:33026618
Nos3decreases response to substanceISONos3 (Mus musculus)6480464CTDNOS3 results in decreased susceptibility to sodium arsenitePMID:16239170
Nos3increases expressionISONOS3 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of NOS3 mRNA; sodium arsenite results in increased expression of NOS3 proteinPMID:12703962
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